Top-Rated Nonprofits in South Carolina 2026
South Carolina has 8 nonprofits with $3.9B in combined revenue. The top-rated organization is Prisma Health Upstate with an Efficiency Score of 79/100.
South Carolina has 8 nonprofits in the IRS Form 990 dataset ranked here by efficiency score. The NonprofitTruth nonprofit efficiency rubric combines financial health / operating reserves (40%), revenue-growth consistency (35%), and officer compensation relative to revenue (25%) into a 0-100 composite.
Reading the ranking: top of the list typically combines healthy operating reserves (the highest-weighted factor) with stable multi-year revenue and reasonable officer compensation. Large hospital and university systems often appear near the top in any state — their scale gives them deep balance sheets and steady revenue. Each nonprofit links to its full Form 990 profile. For donors trying to choose between organizations, the efficiency grade is a useful triage — but the underlying reserve position, the multi-year revenue trend, and the officer-comp ratio matter more than the composite letter on any individual decision.
Top 8 Nonprofits in South Carolina
| # | Organization | Category | Revenue | CEO Pay | Score |
|---|---|---|---|---|---|
| 1 | Prisma Health Upstate | Health | $2.9B | $0 | B (79) |
| 2 | Anderson University | Education | $131.2M | $2.3M | B (76) |
| 3 | National Wild Turkey Federation Inc | Environment & Animals | $54.1M | $1.4M | B (73) |
| 4 | Peace Center Foundation | Arts, Culture & Humanities | $42.8M | $918K | C (56) |
| 5 | Securing Assets For Education | Education | $31.7M | $0 | C (54) |
| 6 | Prisma Health Medical Group Midlands | Education | $348.0M | $578K | D (47) |
| 7 | Charter Institute At Erskine | Education | $244.3M | $761K | D (45) |
| 8 | Furman University | Education | $223.2M | $3.6M | D (41) |
Nonprofit financial data for South Carolina is sourced from IRS Form 990 filings, which all tax-exempt organizations must file annually.
Frequently Asked Questions
Prisma Health Upstate is the top-rated nonprofit in South Carolina with an Efficiency Score of 79/100 (Grade B) and $2.9B in annual revenue.
South Carolina has 8 nonprofits in our database with a combined $3.9B in total revenue.
The Efficiency Score (0-100, A-F) measures a nonprofit's financial structure based on financial health / operating reserves (40%), revenue-growth consistency (35%), and current-officer compensation relative to revenue (25%), all from IRS Form 990 data. Higher scores indicate stronger financial structure. It does not include a program-spending ratio, which our data source does not provide.
Efficiency Score: financial health / operating reserves (40%), revenue-growth consistency (35%), current-officer compensation ratio (25%). No program-spending ratio is included — total program service expenses are not available from the ProPublica Nonprofit Explorer feed.