| 1 | Rush University Medical Center Health | Health | $2.7B | $33.0M | B |
| 2 | Northshore University Healthsystem Health | Health | $2.2B | $25.1M | B |
| 3 | University Of Chicago Education | Education | $4.7B | $21.1M | C |
| 4 | Northwestern Memorial Healthcare Health | Health | $9.1B | $20.3M | A |
| 5 | University Of Chicago Medical Center Health | Health | $2.9B | $20.3M | A |
| 6 | Northwestern Memorial Healthcare Health | Health | $2.1B | $19.8M | C |
| 7 | Osf Healthcare System Health | Health | $3.4B | $17.7M | B |
| 8 | Loyola University Of Chicago Education | Education | $992.7M | $10.8M | B |
| 9 | Depaul University Education | Education | $848.4M | $8.9M | B |
| 10 | Midwestern University Education | Education | $518.1M | $8.1M | C |
| 11 | Illinois Institute Of Technology Education | Education | $364.5M | $8.0M | C |
| 12 | University Of Illinois Foundation Education | Education | $450.3M | $6.0M | C |
| 13 | Art Institute Of Chicago Education | Education | $359.5M | $5.9M | C |
| 14 | Advocate Health And Hospitals Corporation Health | Health | $6.9B | $5.4M | B |
| 15 | The Barack Obama Foundation Arts, Culture & Humanities | Arts, Culture & Humanities | $140.6M | $5.1M | C |
| 16 | Columbia College Chicago Education | Education | $239.2M | $3.8M | C |
| 17 | Institute For The International Education Of Students Education | Education | $126.7M | $3.3M | B |
| 18 | Lyric Opera Of Chicago Arts, Culture & Humanities | Arts, Culture & Humanities | $59.7M | $3.2M | D |
| 19 | Shedd Aquarium Society Environment & Animals | Environment & Animals | $93.0M | $3.1M | C |
| 20 | Bradley University Education | Education | $223.8M | $3.0M | C |
| 21 | Wheaton College Education | Education | $181.6M | $2.7M | C |
| 22 | Chicago Zoological Society Environment & Animals | Environment & Animals | $94.3M | $2.7M | C |
| 23 | Morton Arboretum Environment & Animals | Environment & Animals | $45.1M | $2.6M | D |
| 24 | Kenneth C Griffin Museum Of Science And Industry Arts, Culture & Humanities | Arts, Culture & Humanities | $64.4M | $2.5M | C |
| 25 | North Central College Education | Education | $140.1M | $2.5M | C |
| 26 | Chicago Horticultural Society Environment & Animals | Environment & Animals | $76.9M | $2.3M | D |
| 27 | National Board Of Osteopathic Medical Examiners Inc Arts, Culture & Humanities | Arts, Culture & Humanities | $32.4M | $2.2M | C |
| 28 | Field Museum Of Natural History Arts, Culture & Humanities | Arts, Culture & Humanities | $110.1M | $2.2M | C |
| 29 | Chicago Symphony Orchestra Arts, Culture & Humanities | Arts, Culture & Humanities | $80.8M | $2.1M | D |
| 30 | Augustana College Education | Education | $153.9M | $1.9M | B |
| 31 | National Louis University Education | Education | $126.8M | $1.8M | A |
| 32 | Chicago Public Media Inc Arts, Culture & Humanities | Arts, Culture & Humanities | $33.8M | $1.8M | D |
| 33 | Navy Pier Inc Arts, Culture & Humanities | Arts, Culture & Humanities | $66.9M | $1.8M | C |
| 34 | Lewis University Education | Education | $189.0M | $1.7M | B |
| 35 | Noble Network Of Charter Schools Education | Education | $240.9M | $1.3M | A |
| 36 | Chicago Theatre Group Inc Arts, Culture & Humanities | Arts, Culture & Humanities | $26.8M | $1.3M | C |
| 37 | Aurora University Education | Education | $172.8M | $1.2M | B |
| 38 | Lincoln Park Zoological Society Environment & Animals | Environment & Animals | $48.4M | $1.1M | C |
| 39 | Window To The World Communications Inc Arts, Culture & Humanities | Arts, Culture & Humanities | $39.1M | $986K | C |
| 40 | Ravinia Festival Association Arts, Culture & Humanities | Arts, Culture & Humanities | $53.5M | $871K | C |
| 41 | Paws Chicago Environment & Animals | Environment & Animals | $32.4M | $553K | C |
| 42 | Elevate Energy Environment & Animals | Environment & Animals | $50.9M | $297K | B |
| 43 | Radiant Life Ministries Arts, Culture & Humanities | Arts, Culture & Humanities | $19.7M | $273K | C |