| 1 | University Of Chicago Medical Center Health | Health | 91 | $2.9B | $20.3M | A |
| 2 | Northwestern Memorial Healthcare Health | Health | 85 | $9.1B | $20.3M | A |
| 3 | Noble Network Of Charter Schools Education | Education | 82 | $240.9M | $1.3M | A |
| 4 | National Louis University Education | Education | 82 | $126.8M | $1.8M | A |
| 5 | Elevate Energy Environment & Animals | Environment & Animals | 79 | $50.9M | $297K | B |
| 6 | Rush University Medical Center Health | Health | 78 | $2.7B | $33.0M | B |
| 7 | Aurora University Education | Education | 78 | $172.8M | $1.2M | B |
| 8 | Osf Healthcare System Health | Health | 76 | $3.4B | $17.7M | B |
| 9 | Lewis University Education | Education | 75 | $189.0M | $1.7M | B |
| 10 | Institute For The International Education Of Students Education | Education | 75 | $126.7M | $3.3M | B |
| 11 | Depaul University Education | Education | 73 | $848.4M | $8.9M | B |
| 12 | Advocate Health And Hospitals Corporation Health | Health | 68 | $6.9B | $5.4M | B |
| 13 | Northshore University Healthsystem Health | Health | 66 | $2.2B | $25.1M | B |
| 14 | Loyola University Of Chicago Education | Education | 66 | $992.7M | $10.8M | B |
| 15 | Augustana College Education | Education | 66 | $153.9M | $1.9M | B |
| 16 | National Board Of Osteopathic Medical Examiners Inc Arts, Culture & Humanities | Arts, Culture & Humanities | 63 | $32.4M | $2.2M | C |
| 17 | University Of Chicago Education | Education | 62 | $4.7B | $21.1M | C |
| 18 | Northwestern Memorial Healthcare Health | Health | 62 | $2.1B | $19.8M | C |
| 19 | Columbia College Chicago Education | Education | 61 | $239.2M | $3.8M | C |
| 20 | North Central College Education | Education | 60 | $140.1M | $2.5M | C |
| 21 | Chicago Theatre Group Inc Arts, Culture & Humanities | Arts, Culture & Humanities | 60 | $26.8M | $1.3M | C |
| 22 | Illinois Institute Of Technology Education | Education | 58 | $364.5M | $8.0M | C |
| 23 | Ravinia Festival Association Arts, Culture & Humanities | Arts, Culture & Humanities | 58 | $53.5M | $871K | C |
| 24 | Radiant Life Ministries Arts, Culture & Humanities | Arts, Culture & Humanities | 58 | $19.7M | $273K | C |
| 25 | Window To The World Communications Inc Arts, Culture & Humanities | Arts, Culture & Humanities | 57 | $39.1M | $986K | C |
| 26 | Paws Chicago Environment & Animals | Environment & Animals | 57 | $32.4M | $553K | C |
| 27 | Field Museum Of Natural History Arts, Culture & Humanities | Arts, Culture & Humanities | 56 | $110.1M | $2.2M | C |
| 28 | Chicago Zoological Society Environment & Animals | Environment & Animals | 56 | $94.3M | $2.7M | C |
| 29 | Navy Pier Inc Arts, Culture & Humanities | Arts, Culture & Humanities | 56 | $66.9M | $1.8M | C |
| 30 | Lincoln Park Zoological Society Environment & Animals | Environment & Animals | 56 | $48.4M | $1.1M | C |
| 31 | University Of Illinois Foundation Education | Education | 54 | $450.3M | $6.0M | C |
| 32 | Shedd Aquarium Society Environment & Animals | Environment & Animals | 54 | $93.0M | $3.1M | C |
| 33 | Spencer Foundation Education | Education | 54 | $81.5M | — | C |
| 34 | Midwestern University Education | Education | 53 | $518.1M | $8.1M | C |
| 35 | Wheaton College Education | Education | 53 | $181.6M | $2.7M | C |
| 36 | Kenneth C Griffin Museum Of Science And Industry Arts, Culture & Humanities | Arts, Culture & Humanities | 53 | $64.4M | $2.5M | C |
| 37 | Art Institute Of Chicago Education | Education | 52 | $359.5M | $5.9M | C |
| 38 | The Barack Obama Foundation Arts, Culture & Humanities | Arts, Culture & Humanities | 52 | $140.6M | $5.1M | C |
| 39 | Bradley University Education | Education | 51 | $223.8M | $3.0M | C |
| 40 | Chicago Horticultural Society Environment & Animals | Environment & Animals | 49 | $76.9M | $2.3M | D |
| 41 | Chicago Public Media Inc Arts, Culture & Humanities | Arts, Culture & Humanities | 48 | $33.8M | $1.8M | D |
| 42 | Chicago Symphony Orchestra Arts, Culture & Humanities | Arts, Culture & Humanities | 46 | $80.8M | $2.1M | D |
| 43 | Lyric Opera Of Chicago Arts, Culture & Humanities | Arts, Culture & Humanities | 39 | $59.7M | $3.2M | D |
| 44 | Morton Arboretum Environment & Animals | Environment & Animals | 38 | $45.1M | $2.6M | D |