| 1 | Mass General Brigham Incorporated And Affiliates Group Rtn Health | Health | $22.7B | $105.2M | A |
| 2 | Umass Memorial Health Care Inc Health | Health | $3.7B | $21.2M | A |
| 3 | Childrens Hospital Corporation Health | Health | $2.7B | $19.4M | B |
| 4 | Iso New England Inc Environment & Animals | Environment & Animals | $235.6M | $16.9M | B |
| 5 | President And Fellows Of Harvard College Education | Education | $6.1B | $14.7M | C |
| 6 | Massachusetts Institute Of Technology Education | Education | $5.0B | $13.5M | C |
| 7 | Northeastern University Education | Education | $2.6B | $12.3M | B |
| 8 | Trustees Of Tufts College Education | Education | $1.3B | $10.3M | C |
| 9 | Dana Farber Cancer Institute Medical Research | Medical Research | $3.4B | $9.8M | A |
| 10 | Trustees Of Amherst College Education | Education | $379.3M | $8.5M | D |
| 11 | Boston College Trustees Education | Education | $1.3B | $7.5M | C |
| 12 | Trustees Of The Smith College Education | Education | $587.5M | $7.3M | C |
| 13 | Commonwealth Care Alliance Inc Health | Health | $2.6B | $6.4M | A |
| 14 | Brandeis University Education | Education | $478.7M | $6.4M | C |
| 15 | Mcphs University Education | Education | $342.3M | $5.5M | C |
| 16 | Boston Medical Center Health Plan Inc Health | Health | $4.1B | $5.4M | B |
| 17 | Clean Air Task Force Inc Environment & Animals | Environment & Animals | $46.3M | $5.2M | C |
| 18 | Suffolk University Education | Education | $339.0M | $4.7M | B |
| 19 | Trustees Of Phillips Academy Education | Education | $186.8M | $4.7M | C |
| 20 | Year Up Inc Education | Education | $186.2M | $4.5M | B |
| 21 | Wgbh Educational Foundation Arts, Culture & Humanities | Arts, Culture & Humanities | $220.6M | $4.3M | C |
| 22 | Clark University Education | Education | $226.9M | $4.2M | C |
| 23 | Boston Medical Center Corporation Health | Health | $2.4B | $4.2M | A |
| 24 | Bentley University Education | Education | $347.7M | $4.0M | B |
| 25 | Merrimack College Education | Education | $291.2M | $4.0M | A |
| 26 | Williams College Education | Education | $424.1M | $3.8M | C |
| 27 | Wellesley College Education | Education | $385.6M | $3.8M | C |
| 28 | New England Aquarium Corporation Environment & Animals | Environment & Animals | $65.4M | $3.6M | B |
| 29 | Trustees Of The College Of The Holy Cross Education | Education | $308.2M | $3.6M | C |
| 30 | Harvard Business School Publishing Corporation Arts, Culture & Humanities | Arts, Culture & Humanities | $319.0M | $3.6M | B |
| 31 | Wentworth Institute Of Technology Education | Education | $193.5M | $3.6M | B |
| 32 | Facing History & Ourselves Inc Arts, Culture & Humanities | Arts, Culture & Humanities | $26.2M | $3.5M | D |
| 33 | Museum Of Fine Arts Arts, Culture & Humanities | Arts, Culture & Humanities | $99.6M | $3.4M | F |
| 34 | Trustees Of Mount Holyoke College Education | Education | $283.9M | $3.3M | C |
| 35 | Beth Israel Deaconess Medical Center Inc Health | Health | $2.7B | $2.9M | A |
| 36 | Babson College Education | Education | $344.0M | $2.8M | C |
| 37 | Springfield College Education | Education | $154.9M | $2.8M | B |
| 38 | Boston Symphony Orchestra Inc Arts, Culture & Humanities | Arts, Culture & Humanities | $93.2M | $2.7M | D |
| 39 | Ceres Inc Environment & Animals | Environment & Animals | $43.5M | $2.4M | B |
| 40 | Massachusetts Society For The Prevention Of Cruelty To Animals Environment & Animals | Environment & Animals | $120.3M | $2.3M | B |
| 41 | Wheaton College Education | Education | $154.3M | $2.3M | B |
| 42 | Museum Of Science Arts, Culture & Humanities | Arts, Culture & Humanities | $72.5M | $2.0M | C |
| 43 | Endicott College Education | Education | $195.9M | $1.9M | C |
| 44 | Berklee College Of Music Inc Education | Education | $422.1M | $1.9M | B |
| 45 | Trustees Of Reservations Environment & Animals | Environment & Animals | $50.5M | $1.8M | D |
| 46 | Appalachian Mountain Club Environment & Animals | Environment & Animals | $46.0M | $1.8M | C |
| 47 | Emerson College Education | Education | $331.8M | $1.8M | C |
| 48 | Stonehill College Inc Education | Education | $180.1M | $1.6M | B |
| 49 | Simmons University Education | Education | $225.0M | $1.4M | C |
| 50 | Boston Ballet Inc Arts, Culture & Humanities | Arts, Culture & Humanities | $43.1M | $1.4M | B |