| 1 | Texas Childrens Hospital Health | Health | $3.8B | $51.4M | A |
| 2 | Childrens Health System Of Texas Health | Health | $2.4B | $33.6M | C |
| 3 | The Big 12 Conference Inc Education | Education | $510.7M | $17.2M | C |
| 4 | The Methodist Hospital Health | Health | $2.9B | $16.5M | C |
| 5 | Baylor College Of Medicine Education | Education | $2.6B | $16.4M | B |
| 6 | Methodist Hospitals Of Dallas Health | Health | $1.9B | $15.5M | B |
| 7 | Baylor University Education | Education | $1.5B | $14.0M | B |
| 8 | Texas Christian University Education | Education | $1.1B | $13.2M | C |
| 9 | William Marsh Rice University Education | Education | $1.1B | $12.2M | C |
| 10 | Southern Methodist University Education | Education | $1.0B | $8.6M | C |
| 11 | Memorial Hermann Health System Health | Health | $7.6B | $8.2M | A |
| 12 | Cook Childrens Medical Center Health | Health | $1.9B | $6.2M | A |
| 13 | Idea Public Schools Education | Education | $1.0B | $5.1M | A |
| 14 | Alliance To End Plastic Waste Inc Environment & Animals | Environment & Animals | $80.1M | $4.6M | C |
| 15 | Dallas Symphony Association Inc Arts, Culture & Humanities | Arts, Culture & Humanities | $42.8M | $3.6M | C |
| 16 | Museum Of Fine Arts Houston Arts, Culture & Humanities | Arts, Culture & Humanities | $148.0M | $3.5M | C |
| 17 | Kipp Texas Inc Education | Education | $484.5M | $3.5M | A |
| 18 | Dallas Baptist University Education | Education | $145.7M | $3.5M | A |
| 19 | University Of The Incarnate Word Education | Education | $274.6M | $3.4M | B |
| 20 | Texas Childrens Health Plan Inc Health | Health | $3.1B | $3.4M | A |
| 21 | St Edwards University Education | Education | $181.7M | $3.3M | B |
| 22 | Trinity University Education | Education | $230.2M | $3.2M | D |
| 23 | Texas A&M Foundation Education | Education | $293.3M | $3.1M | C |
| 24 | Harmony Public Schools Education | Education | $548.9M | $2.8M | A |
| 25 | North Texas Public Broadcasting Inc Arts, Culture & Humanities | Arts, Culture & Humanities | $26.9M | $2.4M | D |
| 26 | Dallas Museum Of Art Arts, Culture & Humanities | Arts, Culture & Humanities | $27.8M | $2.3M | F |
| 27 | Uplift Education Education | Education | $304.7M | $2.3M | A |
| 28 | Houston Grand Opera Association Inc Arts, Culture & Humanities | Arts, Culture & Humanities | $30.4M | $2.2M | B |
| 29 | Coastal Conservation Association Environment & Animals | Environment & Animals | $26.5M | $2.2M | C |
| 30 | Yes Prep Public Schools Inc Education | Education | $263.0M | $2.1M | A |
| 31 | Perot Museum Of Nature And Science Arts, Culture & Humanities | Arts, Culture & Humanities | $29.9M | $2.1M | D |
| 32 | Medal Of Honor Museum Foundation Arts, Culture & Humanities | Arts, Culture & Humanities | $35.6M | $2.0M | C |
| 33 | Houston Zoo Inc Environment & Animals | Environment & Animals | $82.5M | $1.6M | C |
| 34 | Houston Museum Of Natural Science Arts, Culture & Humanities | Arts, Culture & Humanities | $82.1M | $1.6M | C |
| 35 | Houston Symphony Society Arts, Culture & Humanities | Arts, Culture & Humanities | $33.4M | $1.5M | C |
| 36 | Riverwalk Education Foundation Inc Education | Education | $128.4M | $1.5M | B |
| 37 | Woodlands Center For The Performing Arts Arts, Culture & Humanities | Arts, Culture & Humanities | $47.4M | $1.4M | B |
| 38 | Great Hearts America Texas Environment & Animals | Environment & Animals | $110.8M | $1.3M | A |
| 39 | San Antonio Zoological Society Inc Environment & Animals | Environment & Animals | $63.8M | $1.3M | B |
| 40 | Dallas Arboretum & Botanical Environment & Animals | Environment & Animals | $27.8M | $1.1M | C |
| 41 | Hope Media Group Arts, Culture & Humanities | Arts, Culture & Humanities | $33.4M | $1.0M | C |
| 42 | Houston Ballet Foundation Arts, Culture & Humanities | Arts, Culture & Humanities | $38.8M | $1.0M | C |
| 43 | The Hobby Center Foundation Arts, Culture & Humanities | Arts, Culture & Humanities | $39.8M | $964K | B |
| 44 | Broadway Dallas Inc Arts, Culture & Humanities | Arts, Culture & Humanities | $27.8M | $952K | B |
| 45 | Dallas Zoo Management Inc Environment & Animals | Environment & Animals | $32.4M | $860K | C |
| 46 | Fort Worth Zoological Association Inc Environment & Animals | Environment & Animals | $53.1M | $834K | B |
| 47 | Southwestern Medical Foundation Education | Education | $72.8M | $809K | C |
| 48 | Emancipet Environment & Animals | Environment & Animals | $24.9M | $754K | B |
| 49 | Menil Foundation Inc Arts, Culture & Humanities | Arts, Culture & Humanities | $30.5M | $726K | C |
| 50 | International American Education Federation Inc Education | Education | $278.6M | $674K | B |