| 1 | Lehigh Valley Hospital Health | Health | 84 | $3.2B | $10.6M | A |
| 2 | Miltons S Hershey Medical Center Health | Health | 83 | $2.6B | $4.3M | A |
| 3 | Thomas Jefferson University Hospital Health | Health | 83 | $2.6B | $2.6M | A |
| 4 | The Childrens Hospital Of Philadelphia Health | Health | 81 | $3.4B | $17.6M | A |
| 5 | Temple University Hospital Inc Health | Health | 80 | $2.1B | $5.4M | A |
| 6 | Gannon University Education | Education | 80 | $166.0M | $2.5M | A |
| 7 | Geisinger Medical Center Health | Health | 79 | $1.9B | $1.4M | B |
| 8 | Commonwealth Charter Academy Charter School Education | Education | 79 | $420.8M | $1.0M | B |
| 9 | Mann Center For The Performing Arts Arts, Culture & Humanities | Arts, Culture & Humanities | 79 | $41.7M | $472K | B |
| 10 | Fairmount Park Conservancy Environment & Animals | Environment & Animals | 78 | $26.1M | $378K | B |
| 11 | Pennsylvania Cyber Charter School Education | Education | 77 | $220.9M | $2.2M | B |
| 12 | Philadelphia College Of Osteopathic Medicine Education | Education | 75 | $173.2M | $4.7M | B |
| 13 | Pennsylvania Horticultural Society Environment & Animals | Environment & Animals | 75 | $37.8M | $785K | B |
| 14 | Thomas Jefferson University Education | Education | 74 | $1.7B | $21.4M | B |
| 15 | Drexel University Education | Education | 74 | $1.4B | $10.7M | B |
| 16 | Widener University Education | Education | 74 | $243.6M | $2.3M | B |
| 17 | Desales University Education | Education | 74 | $129.5M | $1.5M | B |
| 18 | Artsquest Arts, Culture & Humanities | Arts, Culture & Humanities | 74 | $30.9M | $1.0M | B |
| 19 | Wilkes University Education | Education | 73 | $150.8M | $2.0M | B |
| 20 | Mercyhurst University Education | Education | 73 | $149.3M | $1.2M | B |
| 21 | Messiah University Education | Education | 73 | $144.4M | $846K | B |
| 22 | Temple University Health System Inc Education | Education | 72 | $269.9M | $2.8M | B |
| 23 | Arcadia University Education | Education | 72 | $155.4M | $2.6M | B |
| 24 | Duquesne University Of The Holy Spirit Education | Education | 68 | $543.3M | $5.5M | B |
| 25 | University Of Scranton Education | Education | 68 | $257.5M | $4.1M | B |
| 26 | Susquehanna University Education | Education | 67 | $155.8M | $1.8M | B |
| 27 | Whyy Inc Arts, Culture & Humanities | Arts, Culture & Humanities | 66 | $48.1M | $2.8M | B |
| 28 | Temple University Of The Commonwealth System Of Higher Educ Education | Education | 65 | $1.5B | $8.2M | B |
| 29 | Jefferson University Physicians Education | Education | 63 | $486.5M | — | C |
| 30 | Community Services For Children Inc Education | Education | 63 | $240.6M | $413K | C |
| 31 | Gettysburg College Education | Education | 63 | $221.8M | $3.3M | C |
| 32 | Philadelphia University Education | Education | 63 | $163.5M | — | C |
| 33 | University Of Pittsburgh Education | Education | 62 | $3.1B | $7.3M | C |
| 34 | Zoological Society Of Philadelphia Environment & Animals | Environment & Animals | 62 | $43.4M | $1.3M | C |
| 35 | Zoological Society Of Pittsburgh Environment & Animals | Environment & Animals | 61 | $27.6M | $1.0M | C |
| 36 | Milton Hershey School & School Trust Education | Education | 59 | $888.2M | $4.4M | C |
| 37 | Saint Josephs University Education | Education | 59 | $636.8M | $3.2M | C |
| 38 | Pittsburgh Cultural Trust Arts, Culture & Humanities | Arts, Culture & Humanities | 58 | $89.9M | $2.1M | C |
| 39 | Cp 2023 Arts, Culture & Humanities | Arts, Culture & Humanities | 58 | $9.5M | — | C |
| 40 | Trustees Of The University Of Pennsylvania Education | Education | 57 | $9.9B | $53.2M | C |
| 41 | Lehigh University Education | Education | 56 | $695.4M | $4.8M | C |
| 42 | Corporation Of Haverford College Education | Education | 55 | $211.7M | $4.2M | C |
| 43 | Dickinson College Education | Education | 54 | $221.6M | $3.1M | C |
| 44 | Lake Erie College Of Osteopathic Medicine Inc Education | Education | 54 | $201.5M | $3.3M | C |
| 45 | York College Of Pennsylvania Education | Education | 54 | $140.6M | $2.0M | C |
| 46 | Philadelphia Museum Of Art Arts, Culture & Humanities | Arts, Culture & Humanities | 54 | $114.4M | $2.5M | C |
| 47 | Brandywine Conservancy & Museum Of Art Arts, Culture & Humanities | Arts, Culture & Humanities | 53 | $17.9M | $624K | C |
| 48 | Bucknell University Education | Education | 52 | $379.0M | $8.5M | C |
| 49 | Bryn Mawr College Education | Education | 52 | $241.8M | $4.4M | C |
| 50 | Lafayette College Education | Education | 51 | $259.0M | $6.6M | C |